Paroxetine comes as a tablet, suspension, and controlled-release (long-acting) tablet to take by mouth. It is usually taken once daily in the morning and may be taken with or without food. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take paroxetine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Shake the suspension well before using.

Swallow the controlled-release tablets whole; do not split, chew, or crush them.

Continue to take paroxetine even if you feel well. Do not stop taking paroxetine without talking to your doctor, especially if you have taken large doses for a long time. Your doctor will probably want to decrease your dose gradually. This drug must be taken regularly for a few weeks before its full effect is felt.

Side effects from paroxetine are common, and include:

upset stomach
drowsiness
weakness or tiredness
excitement or anxiety
insomnia
nightmares
dry mouth
changes in appetite or weight
Tell your doctor if any of these symptoms are severe or do not go away:

constipation
difficulty urinating
frequent urination
blurred vision
changes in sex drive or ability
excessive sweating
If you experience any of the following symptoms, call your doctor immediately:

jaw, neck, and back muscle spasms
slow or difficult speech
shuffling walk
persistent fine tremor or inability to sit still
fever, chills, sore throat, or flu-like symptoms
difficulty breathing or swallowing
severe skin rash
yellowing of the skin or eyes
irregular heartbeat

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

drowsiness
coma
upset stomach
tremor
rapid pounding or irregular heartbeat
confusion
vomiting
dizziness
seizures
fainting
blurred vision
yellowing of the skin and eyes
seeing things or hearing voices that do not exist (hallucinating)
difficulty urinating

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to paroxetine.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription

If you take paroxetine once a day in the morning, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. If you take paroxetine once a day at bedtime and do not remember to take it until the next morning, skip the missed dose. Do not take a double dose to make up for a missed one.

Paroxetine (Paxil) is used to treat depression, obsessive-compulsive disorders, panic attacks, social anxiety disorder, generalized anxiety disorder, and posttraumatic stress disorder. Paroxetine controlled-release (Paxil CR) is used to treat depression and panic attacks. Paroxetine is in a class of medications called selective serotonin reuptake inhibitors (SSRIs). It works by increasing the amounts of certain natural substances in the brain.

Paroxetine is also used occasionally to treat headaches, diabetic leg pain, and premature ejaculation. Talk to your doctor about the possible risks of using this drug for your condition. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

Before taking paroxetine,

tell your doctor and pharmacist if you are allergic to paroxetine or any other drugs.
tell your doctor and pharmacist what prescription and nonprescription drugs you are taking or have taken within the last 2 weeks, especially anticoagulants [warfarin (Coumadin)]; antidepressants; antihistamines; cimetidine (Tagamet); digoxin (Lanoxin); levodopa (Sinemet, Larodopa); lithium (Eskalith, Lithobid); MAO inhibitors [phenelzine (Nardil), tranylcypromine (Parnate)]; medication for high blood pressure, seizures, Parkinson's disease, asthma, colds, or allergies; muscle relaxants; phenobarbital; procyclidine (Kemadrin); sedatives; sleeping pills; sumatriptan (Imitrex); theophylline (Theo-Dur); thioridazine (Mellaril); thyroid medications; tranquilizers; tryptophan; and vitamins.
tell your doctor if you have or have ever had glaucoma; an enlarged prostate; difficulty urinating; seizures; an overactive thyroid gland; or liver, kidney, or heart disease.
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking paroxetine, call your doctor immediately.
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking paroxetine.
you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you.
remember that alcohol can add to the drowsiness caused by this drug.
tell your doctor if you use tobacco products. Cigarette smoking may decrease the effectiveness of this drug.
plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Paroxetine may make your skin sensitive to sunlight.